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贵州彝、瑶族及汉族HBV感染与IL-10-819相关性

Association between IL-10-819 polymorphism and susceptibility to hepatitis B virus infection in Han, Yi and Yao minority of Guizhou

    摘要
  • 摘要: 目的 探讨贵州世居少数民族——威宁、黔西彝族,荔波瑶族以及荔波汉族人群白细胞介素-10-819(IL-10-819)基因多态性与乙型肝炎病毒易感性的相关性.方法 对500名不同民族研究对象采用序列特异性引物—聚合酶链式反应(PCR-SSP)方法分析IL-10-819位点多态性.结果 贵州威宁彝族、黔西彝族、荔波瑶族及汉族人群的IL-10-819位点基因型频率分别为:纯合突变型(TT)为40.74%、44.80%、34.30%、50.40%;杂合子(CT)为40.74%、49.50%、54.20%、43.00%;野生型(CC)为18.52%、5.70%、11.45%、6.60%;贵州威宁彝族、黔西彝族、荔波瑶族、荔波汉族IL-10-819基因型频率分布差异有统计学意义(P<0.05);IL-10-819基因型频率在黔西彝族、荔波汉族感染组与非感染组间分布差异有统计学意义(P<0.05).结论 IL-10基因启动子区-819位点多态性可能与贵州汉、瑶、彝族的乙肝易感性相关;IL-10基因多态性可能是乙肝易感的危险因素之一.

     

    Abstract: Objective To investigate the association between in terluekin 10(IL-10)-819 gene polymorphism and susceptibility to hepatitis Bvirus(HBV) infection in Han, Yi and Yao mino rity in Guizhou provnce.Methods We selected 500 volunteers from Guizhou provice.A llelic frequencies of IL-10-819 were measured with PCR SSP.Results There was a significant difference in IL-10-819 genotype frequencies between the minority and the whole population(P < 0.05).The distributions of geno type frequency of IL 10-819 were statistically different among Yao ethnic and Han ethnic in Libo, Yi ethnic in Q ianxi and Yi ethnic in We ining, and Han ethnic in Libo(P < 0.05).IL-10-819 polym orphism was associated with HBV infection in Yi ethnic in Qianxi and Hanethnic in Libo.Conclusion IL-10-819 g enepolymorphisms influence susceptibility to HBV infection in Han, Yao, Yi population in Guizhou.The study suggests that IL-10-819 genepolymorphisms maybe a risk factor for HBV in fection.

     

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