Abstract: Objective To investigate the association between interleukin 10(IL-10)gene promoter polymorphism and obessive-compulsive disorder(OCD).Methods Genotyping for IL-10 gene SNP592A/C(rs1800872), 1082 A/G(rs1800896), and 819T/C(rs1800871)were performed for 381 OCD patients and 485 health controls with polymerase chain reaction and restriction fragment length polymorphism techniques.The OCD patients were assessed with Yale-Brown Obsessive-Compulsive Scale(Y-BOCS).Results There were no significant differences in the frequency distribution of genotype and allele of IL-10 gene(rs1800872, rs1800896, and rs1800871)between OCD patients and health controls(P>0.05).There were no significant differences in the freqency distribution of genotype and allele of 3 single nucleotide polymorphisms(SNPs)for the females of different onset age between OCD group and control group(P>0.05).There were significant differences in the freqency distribution of genotype (χ²=6.51, P=0.039) and allele (χ²=6.59, P=0.01;odds ratioOR=1.84, 95% confidence interval95% CI=1.15-2.95) of IL-10 gene (rs1800896) for the males between OCD patients and health controls, and there were significant differences in the freqency distribution of genotype(χ²=8.08, P=0.02) and allele(χ²=6.97, P=0.008;OR=1.95, 95%CI=1.18-3.23)of IL-10 gene (rs1800896) between female OCD group and male OCD group.Conclusion The results support a role for IL-10 gene(rs1800896)in conferring susceptibility to OCD in male.