Abstract: Objective To investigate the association of excision repair cross-complementation group 1(ERCC1)genetic variations(262G>T and-433 T>C)with gastric cancer susceptibility.Methods A case-control study was conducted among 230 patients with gastric cancer and 460 controls.Genotypes of ERCC1 262 G>T and -433T>C were determined with polymerase chain reaction-based restriction fragment length polymorphism(PCR-RFLP)and Taqman real-time polymerase chain reaction.Logistic regression analysis was performed to estimate the odd ratios(ORs)and 95%confidence intervals(95%CI)associated with genetic variants of ERCC1.Results An OR of 0.62(0.40-0.97)for gastric cancer was observed for the subjects with ERCC1 262 TT genotype compared with those with 262 GG genotype.When stratified by smoking status,the ORs(95%CI)of the carriers of ERCC1 262GT or TT genotype for nonsmokers and smokers were 0.60(0.38-0.93)and 1.00(0.55-1.82),respectively.There was no significant difference in ERCC1-433T>C genotype distribution between gastric cancer cases and the control.Conclusion ERCC1 262G>T variant may contribute to a decreased susceptibility of gastric cancer.