Abstract: ObjectiveTo investigate the relationship between hyperuricemia and cardiovascular risk factors and the clustering of the risk factors among middle-aged and elderly physical examinees,and to provide basis for effective prevention of hyperuricemia.MethodsA cross-sectional clustering sampling survey was conducted in physical examinees registered in the Department of Healthy Management of General Hospital of Guangzhou Military Region.Totally 1 176 valid subjects aged from 45 to 75 years taking annual physical examination at 14 medical examination centers were required to complete a questionnaire survey,physical examination and laboratory detection.ResultsMean age,the level of triglyceride and creatinine,body mass index,waist-hip ratio,and the prevalence rate of hypertension in the hyperuricemia group were higher than those the non-hyperuricemia group,and the mean level of high-density lipoprotein cholesterol(HDL) of hyperuricemia group was lower than that of the non-hyperuricemia group in both men and women.In addition,the prevalence rate of diabetes was higher in the hyperuricemia group among women.After adjusting for sex and alcohol drinking habit,the results of multivariate analyses showed that factors associated with hyperuricemia(odds ratioOR) (95% confidence interval95%CI,) were high density lipoprotein cholesterol(OR=1.923,95%CI:1.304-2.834),abdominal obesity(OR=1.482,95%CI:1.001-2.194) in the men,HDL(OR=0.387,95%CI:0.222-0.676),creatinine(OR=1.061,95%CI:1.037-1.086),obesity(OR=6.345,95%CI:2.524-15.952) in the women.With the increasing number of cardiovascular risk factors,the proportion of hyperuricemia patients increased significantly.After adjusting for age,sex and alcohol drinking,the risk of hyperuricemia increased significantly along with the increased number of risk factors.ConclusionAmong the middle-aged and elderly populations,the prevalence rate of hyperuricemia is higher in women than in men.The level of high density lipoprotein cholesterol,abdominal obesity are significantly associated with hyperuricemia in men.The level of HDL and creatinine,and obesity are significantly associated with hyperuricemia in women.Hyperuricemia subjects tend to have a clustering of cardiovascular risk factors.