Abstract: ObjectiveTo study the association of stroke incidence with cerebral vascular hemodynamics index (CVHI)and blood pressure level and to provide reference for the prevention and control of stroke.MethodsCVHI dettermination and blood pressure measurement were conducted among 10 565 participants aged 40 years and over selected with cluster sampling from a town in Fengxian county of Shanghai city.The participants were grouped according to CVHI and blood pressure level and followed-up from March of 2003 to December of 2010 for the observation and comparison of stroke incidence in each group.ResultsAmong the participants,there were 191 incidences of stroke(including cerebral hemorrhage and cerebral infarction),with an incidence rate of 1.81% during the follow-up period.The onset risks were 0.68%,2.46%,5.25%,and 8.22% for the participants with CVHI of ≥75,50-74,25-49 and 0-24.The incidence of stroke increased with the decrease of CVHI(χ_trend² =271.155,P<0.001).The incidences of stroke for control group,hypertension group,first phase hypertension group,second phase hypertension group,and third phase hypertension group were 0.98%,2.52%,2.79%,6.42%,and 3.30%,respectively,and the incidence of stroke increased with the increment of blood pressure.(χ_trend²=271.155,P<0.001).ConclusionThe incidence of stroke is positively associated with blood pressure and inversely related to CVHI among residents aged more than 40 years.