Abstract: Objective To examine the levels and change trend of total cholesterol(TC),triglyceride(TG) and high density lipoprotein cholesterolo(HDL-C) among urban residents aged 6 years and older in Guangdong province.Methods Plasma lipids of 3 601 subjects aged 6 years and older were determined.Results The mean of TG,TC and HDL-C were 1.44 mmol/L,4.87 mmol/L and 1.38 mmol/L,respectively.The levels of TG,TC and HDL-C were increased with the increment of age.The means of TG and TC among the urban women aged 55 years and older were higher than those in men.The mean of HDL-C in women of most of age groups was higher than that in men.The prevalence of high TG was higher for urban residents aged 45 to 65 years.The prevalence of high TC increased with the increment of age.The prevalence of low HDL-C declined with the increase of age.Conclusion The levels of plasma lipids in urban residents of Guangdong province increased in the last decade.Special attention should be paid to higher prevalence of hyperlipidemia among the men aged 45 years and over and women aged 55 years and over.