Abstract: Objective To explore the association of the interaction between tryptophan hydroxylase isoform(TPH-2)gene rs4570625 and G1463A with uniplor deression.Methods We collected specimens of peripheral blood from 300 uniplor depression patients and 300 healthy controls in a mental hospital in Harbin city.PCR was used to detect the polymorphisms of rs4570625 and G1463A, and logistic regression model was used to analyze the interaction of rs4570625 and G1463A.Results The genotypic frequences of the single nucleotide polymorphism(SNP)did not deviant from Hardy-Weinberg equilibrium in both case and control groups(P>0.05).Compared with the control group, no significant difference in genotypes and alleles of TPH2 gene rs4570625 was found in patient group(P>0.05).There were significant differences in G/G, A/G, and A/A frequencies of TPH2 gene G1463A between the patient group(6.0%, 18.3%, and 75.7%)and control group(57.3%, 2%, and 40.7%).There was a positive interaction between rs4570625 and G1463A in uniplor depression patients(odds ratio OR_AB=5.539, OR_A=0.747, OR_B =0.024, OR_I>1).Conclusion The interaction between rs4570625 and G1463A plays an important role in the incidence of uniplor depression.