高级检索

维生素D受体基因VDR与胃癌易感性关系

Relationship between VDR genetic polymorphisms,environmental risk factors and gastric cancer susceptibility：a case-control study

    摘要
  • 摘要: 目的 探讨江苏省南京市汉族居民维生素D受体（VDR）基因多态性与胃癌易感性关系，并分析其与环境危险因素的交互作用。方法 采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术对585例胃癌患者及其对照进行VDR基因第8外显子AapI位点、第9外显子TaqI位点的单核苷酸多态性（SNP）分析，分析VDR基因多态性与胃癌易感性的关系。结果 病例组VDR ApaI A和a等位基因频率为40.60%和59.40%，对照组分别为41.54%和58.46%，差异无统计学意义；病例组VDR TaqI T和t等位基因频率分别为96.90%和3.10%，对照组分别为93.50%和6.50%，差异有统计学意义（χ2=6.676，P<0.05）；病例组VDR ApaI的aa、Aa及AA基因型频率分别为33.16%、52.48%和14.36%，对照组分别为29.92%、57.09%和12.99%，差异无统计学意义；病例组VDR Taq I的TT、Tt及tt基因型频率分别为91.97%、7.86%和0.17%，对照组分别为87.35%、12.31%和0.34%，差异有统计学意义（χ2=6.757，P=0.034）；VDR ApaI和TaqI与消化系统疾病史、肿瘤家族史、暴饮暴食、新鲜水果摄入少、精神压抑有交互作用。结论 VDR TaqI多态性与胃癌易感性相关。

     

    Abstract: Objective To explore the relationship between vitamin D receptor(VDR)genetic polymorphisms and gastric cancer susceptibility and the interaction between VDR and environmental risk factors.Methods A 1:1 matched case-control study was carried out in Nanjing area.Polymerase chain reaction-restriction fragment length polymorphisms(PCR-RFLP)technology was used to determine the genetic polymorphisms of VDR and epidemiology data on environmental exposure were collected.Results The frequencies of VDR-ApaI A and a allele in the case group were 40.60%and 59.40%,while those in the control group were 41.54%and 58.46%,without significant differences between the two groups.The frequencies of VDR-TaqI T and t allele in the case group were 96.90%and 3.10%,while those in the control group were 93.50%and 6.50%,without significant differences between the two groups(χ2=6.676,P<0.05).The frequencies of VDR-ApaI genotype aa,Aa,and AA in the case group were 33.16%,52.48%,and 14.36%,while those in the control group were 29.92%,57.09%,and 12.99%,respectively,without significant differences between the two groups.The frequencies of VDR-TaqI genotypes TT,Tt,and tt in the case group were 91.97%,7.86%,and 0.17%,while those in the control group were 87.35%,12.31%,and 0.34%,respectively,with significant differences between the two groups(χ2=6.757,P<0.05).There were interactions between genotype of VDR and digestive system disease history,family history of tumor,having less fruit,and depression.Conclusion There are associations between VDR poly-morphisms and gastric cancer.

     

    • HTML全文
    • 参考文献(14)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回