Abstract: Objective To explore the correlation between skin lesion and DNA oxidative damage in the women exposed to low concentration arsenic.Methods Fifty-four female cases exposed to arsenic in drinking water and 18 females controls were investigated.The urine samples were collected from the females and measured for urinary total arsenic and 8-hydroxy-2'-deoxyguanosine(8-OHdG).Results The average total urinary arsenic was 22.90±6.41 μg/gCr and the average contert of 8-OHdG was 11.78±2.95 μg/gCr for the chronic arsenic exposure,both of them were significantly higher than those of the control.Significant positive correlations were found between urinary 8-OHdG and total arsenic(r=0.893,P<0.05)as well as urinary 8-OHdG and the grade of skin lesion(r=0.847,P<0.05).The level of urinary 8-OHdG was associated with an increased risk of skin lesion in arsenic exposed cases(odds ratio=2.838,P<0.05).Conclusion A clear dose-response relationship was observed between low arsenic exposure and skin lesion.The results suggest low arsenic exposure could lead to oxidative DNA damage and 8-OHdG can be used as a stable biomarker for arsenic-induced oxidative damage.