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不同感染途径丙型肝炎患者HCV基因分型

王佳佳, 唐筛娣, 丁伟良, 许可, 喻荣彬, 王洁, 张云

王佳佳, 唐筛娣, 丁伟良, 许可, 喻荣彬, 王洁, 张云. 不同感染途径丙型肝炎患者HCV基因分型[J]. 中国公共卫生, 2013, 29(6): 809-811. DOI: 10.11847/zgggws2013-29-06-09
引用本文: 王佳佳, 唐筛娣, 丁伟良, 许可, 喻荣彬, 王洁, 张云. 不同感染途径丙型肝炎患者HCV基因分型[J]. 中国公共卫生, 2013, 29(6): 809-811. DOI: 10.11847/zgggws2013-29-06-09
WANG Jia-jia, TANG Shai-di, DING Wei-liang.et al, . Hepatitis C virus genotyping in patients infected with HCV by different routes in Jiangsu province[J]. Chinese Journal of Public Health, 2013, 29(6): 809-811. DOI: 10.11847/zgggws2013-29-06-09
Citation: WANG Jia-jia, TANG Shai-di, DING Wei-liang.et al, . Hepatitis C virus genotyping in patients infected with HCV by different routes in Jiangsu province[J]. Chinese Journal of Public Health, 2013, 29(6): 809-811. DOI: 10.11847/zgggws2013-29-06-09

不同感染途径丙型肝炎患者HCV基因分型

基金项目: 

国家自然科学基金(81072343;81273146;81102165);江苏省自然科学基因(BK2011840)

详细信息
    作者简介:

    王佳佳(1987-),男,江苏扬州人,硕士在读,研究方向:传染病分子流行病学。

    通讯作者:

    王洁,张云

    王洁,张云

  • 中图分类号: R183.9

Hepatitis C virus genotyping in patients infected with HCV by different routes in Jiangsu province

  • 摘要: 目的探讨江苏省丙型肝炎病毒(HCV)基因型的分布及其与感染途径、肝功能等因素的关系。方法按照Simmonds分型方法对505例不同感染途径的丙型肝炎患者进行HCV基因型分型检测并分析年龄、性别、肝功能以及感染途径与HCV基因型的关系。结果505例HCV RNA阳性标本中,1a型8例(1.6%),1b型348例(68.9%),2型24例(4.8%),3型40例(7.9%),1b/2混合型67例(13.3%),1b/3混合型13例(2.6%),2/3混合型4例(0.8%),1a/1b混合型1例(0.2%);不同性别、年龄人群HCV基因型分布差异均无统计学意义(均P>0.05);不同HCV基因型人群丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)水平差异均无统计学意义(均P>0.05);不同感染途径人群HCV基因型分布差异有统计学意义(χ2 =73.348,P <0.001)。结论江苏省丙型肝炎患者HCV基因型以1b型为主,1a型HCV在中国大陆地区流行程度有扩大趋势,HCV基因型与其感染途径有关。
    Abstract: ObjectiveTo investigate the distribution of hepatitis C virus(HCV) genotype among HCV infected patients in Jiangsu province and its relationship to infectious route and conditions of hepatic function. MethodsThe HCV genotypes of the patients were determined with PCR products of 5' untranslated region(UTR) digested with restriction endonucleases,and the relationships of genotype to age,gender,liver function and infectious route were analyzed. ResultsAmong 505 HCV RNA-positive serum samples,there were 8(1.6%) of genotype 1a,348(68.9%) of 1b,24(4.8%) of type 2,40(7.9%) of type 3,67(13.3%) of 1b/type 2,13(2.6%) of 1b/type 3,4(0.8%) of type 2/type 3,and 1(0.2%) of 1a/1b,respectively.The HCV genotype distribution was not different among the subjects of different gender and age (Page=0.445,Psex=0.083) but was significantly different among the patients infected with HCV by different routes(P<0.001).The alanine aminotransferase(ALT) and asparate aminotransferase(AST) levels did not show statistically significant differences among the patients infected with different genotype HCV(PALT=0.781,PAST=0.217). ConclusionType 1b is the predominant HCV genotype in Jiangsu province and HCV 1a genotype shows an increased prevalent trend in mainland of China.HCV genotypes of the HCV infected patients are related to their infectious routes.
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出版历程
  • 收稿日期:  2013-02-15
  • 刊出日期:  2013-06-09

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