Abstract: Objective To describe the time series characteristics of morbidity and mortality of conventionally vaccinable diseases in Guangxi Zhuang Autonomous Region between 1989 and 2008 and to provide reference to planed immunization work in the area.Methods The report data on conventionally vaccinable diseases in Guangxi between1989 and 2008 were analyzed and morbidity,mortality and the changing trend of the diseases were described.Results There were totally 1 191 789 incidents and 5 382 deaths of the conventionally vaccinable diseases in Guangxi from 1989 to 2008,with an annual morbidity rate of 124.29/100 000 and a mortality rate of 0.53/100 000.The disease with the highest incidence was hepatitis B(3.02/100 000) in 1989 and the disease was substituted by tuberculosis(131.41/100 000) in 2008.The incidence time series indicated that the morbidity of hepatitis B and tuberculosis increased from1989 to 2008,that of measles descended from 1993 after an outbreak epidemics,and that of tetanus,pertussis,diphtheria,and polio declined overall.The mortality of tetanus was the highest among 7 conventionally vaccinable diseases between 1989 and 2003,but that of tuberculosis was the highest from 2004 to 2008.Mortality time series indicated that the mortality of all conventionally vaccinable diseases,including measles,tetanus,pertussis,diphtheria,and polio,decreased from 1989 except for that of tuberculosis and hepatitis B increased in the period.Conclusion There are decline trends in the morbidity and mortality for measles,tetanus,pertussis,diphtheria,and polio,but the morbidity and mortality of hepatitis B and tuberculosis show an increase trend in Guangxi between 1989 and 2008.