Abstract: ObjectiveTo investigate the liver fibrosis progression in hepatitis C virus(HCV)infected patients and its risk factors among paid blood donors in Wangying village of Henan province.MethodsTotally 149 HCV monoinfected and 106 HCV/human immunodeficiency virus(HIV)coinfected paid blood donors were enrolled into a cohort and followedup.The blood samples were collected for HCV or HIV antibody test and CD4T,CD8T cell counts,and B ultrasonic examination was performed for liver fibrosis detection.Cox regression analysis was used to explore the risk factors of liver fibrosis in HCV patients.ResultsAmong the subjects,25.88% (66/255)were diagnosed as liver fibrosis and the incidence of liver fibrosis was different between the patients of different gender,with and without highly active anti-retroviral therapy,different counts of CD4T and CD8T cell,and types of virus infection(χ²=10.453,P<0.01).Considering liver fibrosis as the end point,the median survive time of coinfected group was 5.74 years earlier than the monoinfected group,with a significant difference(P<0.05).Cox regression analysis indicated that the only risk factor of liver fibrosis was types of virus infected (χ²=10.453,P<0.01).Conclusioncompared with the HCV monoinfected,HCV/HIV coinfected could increase the risk of hepatic fibrosis and accelerate the progression of liver fibrosis.